Biostatistical
Methods II: Regression Analysis (Biometry 701)
Spring 2009
Description:
This is a one-semester course intended for graduate students pursuing degrees
in biostatistics and related fields such as epidemiology and
bioinformatics. Topics covered will include linear, logistic, poisson, and Cox regression. Estimation,
interpretation, and diagnostic approaches will be discussed. Software
instruction will be provided in class in R and Stata.
Students will be evaluated via homeworks (55%), two
in-class exams (35%) and class participation (10%). This is a four credit
course.
Textbook:
Applied Linear Statistical Models. Kutner, Nachtsheim, Neter
and Li. McGraw-Hill, Fifth Edition
Prerequisites:
Biometry 700
Course Objectives: Upon
successful completion of the course, the student will be able to
1. Apply,
interpret and diagnose linear regression models
2. Apply,
interpret and diagnose logistic, poisson and Cox regresssion models
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Instructor: |
Elizabeth
Garrett-Mayer |
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Website: |
http://people.musc.edu/~elg26/teaching/methods2.2009/methods2.2009.htm |
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Contact
Info: |
Hollings
Cancer Center, Rm 118G |
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garrettm@musc.edu (preferred mode of
contact is email) |
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792-7764 |
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Time: |
Mondays and
Wednesdays, 1:30-3:30 |
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Location: |
Cannon 301,
Room 305V |
Lectures:
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Date |
Topic |
PDF |
Computing |
Reading
Assignment |
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W Jan 7 |
Introduction to regression; simple linear regression (SLR) |
Ch 1 |
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M Jan 12 |
no class!
Instructor at workshop in MD |
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W Jan 14 |
Linear model properties; software tutorial |
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R-intro.pdf (supplemental) |
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M Jan 19 |
no
class! MLK Jr. Day |
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W Jan 21 |
Linear model properties; software tutorial |
(see Jan 14) |
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Ch 2 |
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M Jan 26 |
Inferences and assumption checking in SLR |
Ch 6 |
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W Jan 28 |
SLR Diagnostics |
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M Feb 2 |
Diagnostics
(continued);Correlation; Intro to Multiple Linear Regression |
Ch 5 |
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W Feb 4 |
Hypothesis
testing in LR |
Ch 2, Ch 6 |
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M Feb 9 |
MLR |
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Ch 2, Ch 6 |
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W Feb 11 |
Forms for
predictors |
Ch 8 |
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M Feb 16 |
interactions |
Ch 7 |
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W Feb 18 |
F-tests and
ANOVA |
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M Feb 23 |
F-tests and
Coefficients of Determination |
Ch 7 |
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W Feb 25 |
Multicollinearity |
Ch 7 |
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M Mar 2 |
MLR Model
Building |
Ch 9 |
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W Mar 4 |
MLR:
final comments |
Ch 10 |
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M Mar 9 |
NO CLASSES: SPRING BREAK! |
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W Mar 11 |
NO CLASSES: SPRING BREAK! |
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M Mar 16 |
no class!
Instructor at meeting in TX |
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W Mar 18 |
MLR final
comments |
(see W Mar
4) |
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M Mar 23 |
Introduction
to logistic regression |
Ch 14 |
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W Mar 25 |
Inference
and link functions |
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M Mar 30 |
Likelihood
ratio tests and deviance |
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W Apr 1 |
Goodness of
fit, Information criteria, |
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M Apr 6 |
ROC
Analysis |
(see
lect16) |
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W Apr 8 |
Logistic
regression for case control studies |
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M Apr 13 |
Catch up
day |
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W Apr 15 |
Logistic
regression for matched case control studies |
class
canceled |
enjoy doing your taxes! |
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M Apr 20 |
Introduction
to survival data |
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http://jslhr.asha.org/cgi/reprint/42/2/432 http://www.walkerbioscience.com/pdfs/Survival%20analysis.pdf |
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W Apr 22 |
Survival
analysis |
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M Apr 27 |
Cox
regression |
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W Apr 29 |
Exam 2 |
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Datasets:
Ischemic Heart Disease: IschemicHeartDisease.csv
Prostate Cancer Dataset: Prostate.csv (codebook: prostate.txt)
ICU dataset: icu.csv
(codebook: icu.txt)
Kidney Dialysis: kidneydialysis.csv
Homeworks:
Homework
1.pdf Due
Mon 01/26/09
Homework2.doc
Due
Wed 02/04/09
homework3.doc
Due Wed 02/18/09
homework4.doc
Due Fri 03/06/09
homework5.doc Due
Wed 04/08/09
homework6.doc Due
Mon 04/20/09
homework7.doc Due
Wed 04/29/09
EXAMS:
exam1.doc
Due Mon 03/09/09
Articles:
gillison.pdf: Case control study
of HPV16 and Oropharyngeal Cancer
hanley&mcneill.pdf:
Comparing AUCs for ROC curves based on the same data
chaves.pdf: Nomograms
for mobility disability
Computing:
R
website: http://cran.r-project.org/
R tutorial:
R-intro.pdf
Stata website: http://www.stata.com/