Early Phase Clinical Trials
Working Group
About us: We
are a group of biostatisticians at the Medical University of South Carolina who
are interested in learning more about and developing methodology related to
early phase clinical trials.
Some of our applied areas of
interest are cancer and neurology.
Current members:
Elizabeth Garrett-Mayer, Sharon Yeatts, Yuko Palesch, Dipankar Bandyopadhyay, Emily Kistner-Griffin, Hiya Banerjee, Renee Martin,
Amy Wahlquist, Kent Armeson, Cody Chiuzan, Jody
Ciolino, Joyce Nicholas, Angela Wu, Bethany Wolf, Betsy Hill.
Our meetings: We
meet the third Monday of the month from 1:15-2:30 in Room 304 of Cannon Place
(135 Cannon St.).
Interested in joining? Please
contact
us to join our email list.
Our calendar:
|
Date |
Presenter |
Topic |
Links to
Paper(s) |
|
September
20, 2010 |
Liz
Garrett-Mayer |
Organizational
meeting and overview |
Clinical
Cancer Research volume with focus on Phase 0 trials |
|
October 18,
2010 |
Amy Wahlquist |
Designing
Phase 0 Cancer Clinical Trials |
|
|
November
15, 2010 |
Cody
Chiuzan |
Outcome
adaptive methods in dose-finding trials |
|
|
December
20, 2010 |
Yuko Palesch |
Futility
Designs |
|
|
January
24*, 2011 |
Jody
Ciolino |
Modified
toxicity probability interval (mTPI) |
|
|
February
21, 2011 |
Liz
Garrett-Mayer |
Likelihood
early stopping designs in phase II clinical trials |
Early stopping
for phase II cancer studies: a likelihood
approach (long) Early stopping
for phase II cancer studies: a likelihood
approach (short) |
|
March 21,
2011 |
Betsy Hill |
Seamless Phase
I-II Trial Design for Assessing Toxicity and Efficacy for Targeted Agents. |
* this is the 4th Monday, due to MLK Jr
Holiday on the 3rd Monday.
Some useful references:
Clinical Cancer
research volume with focus on Phase I trials
EWOC (Tighiouart M, Rogatko A, Babb
JS.)
Ideas for future discussion
topics:
Software and resources for
implementing early phase trial designs
Phase 0 trials
Dose
finding trials in non-toxic agents.
Designing early phase studies with
targeted agents.
White papers on BioPharmNet website