NIAAA grant P50 AA010761.   This grant is a component of our P50 Alcohol Center. A combination of in vivo ethanol exposure, slice electrophysiology, imaging and behavioral approaches are used to define the actions of ethanol on neurons located in the prefrontal and orbitofrontal cortex. 

 

Persistent activity and membrane bistability in mPFC/Hippocampus/VTA slice co-cultures

Dendritic spine characterization in lateral orbitofrontal cortex neuron

Left: Chronic ethanol exposure protocol. Bottom left: CIE enhances spiking in lateral orbitofrontal cortex neuron. Bottom right: CIE mice show impaired OFC-dependent reversal learning


back