Research in the Mulholland Lab aims to unlock the molecular mechanisms by which chronic alcohol leads to escalation of voluntary consumption, aberrant plasticity, and alcohol withdrawal hyperexcitability. We combine various techniques, such as confocal imaging and 3D image analysis, electrophysiology, biochemistry, pharmacology, and behavior, to understand the cellular and molecular changes that contribute to alcohol dependence.
Dr. Patrick Mulholland is interested in how chronic alcohol exposure alters the structure and function of glutamatergic synapses. Current efforts in the Mulholland Lab are focused on potassium channel and glutamate receptor membrane trafficking and adaptations in the morphology of dendritic spines in the hippocampus, cortex, and nucleus accumbens. More recently, Dr. Mulholland has embarked on quantitative proteomic studies to characterize neuroadaptations in tripartite synapses induced by prolonged alcohol exposure. These studies aim to define the cellular basis for cognitive dysfunction and relapse to alcohol-seeking behaviors in order to identify novel therapeutic targets to treat alcohol use disorders.
Our lab is located on the campus of the Medical University of South Carolina in the Institute of Psychiatry building.
67 President St
Institute of Psychiatry
Room 255 North
Charleston, SC 29425