Kenny Vaden. I work with
Dr. Mark Eckert in the
Hearing Research Program at the Medical University
of South Carolina, in
I completed my Ph.D. studies in Psychology from the Department of Cognitive Sciences
at UC Irvine in 2009. My dissertation research
focused on the cortical substrates of speech recognition, advised by
Dr. Greg Hickok, which involved
developing a lexical database (IPhOD) and
conducting behavioral and fMRI experiments on speech recognition.
My postdoctoral training builds on my graduate work with a broader focus on
how speech recognition and neural networks change with increasing age. Although our
typical experiences with speech communication seem simple and effortless, changes in noise
level, hearing loss, age, and brain structure or function can impact the difficulty of speech
recognition - particularly for older adults. This difficulty may reflect declines in
neural systems that must work together to integrate information in speech and access meaning.
Irvine Phonotactic Online Dictionary.
The IPhOD is a large collection of English words and pseudowords that I developed at
UC Irvine for research on speech perception and production. The IPhOD allows researchers
to select items for experiments, based on measures related to speech sounds or to answer
questions such as: Which contains more unusual sound-sequences, dog or cat?
Which sounds like fewer other English words? What are some nonsense words with similar
lexical-phonological qualities? All of the tools on the website are freely available for
academic and personal use. [Link]
Neuroimaging Analysis with Missing Data. Aging and clinical research presents
unique challenges to fMRI analysis that include variability in motion and morphology, which can result in missing data.
In Vaden et al. (2012),
we demonstrated that brain regions are often excluded from group level statistical tests
due to a small number of missing values. We also showed that multiple imputation can be used to
perform statistic tests and estimate group level results in regions with predictable missingness.
We developed a toolkit that can be downloaded from NITRC.ORG, to implement this technique for
other group level fMRI analyses.
Pythagorean Displacement and Motion Regressors.
Head movement in the scanner can result in fMRI artifacts that are related to position as well as motion.
A common strategy to control these artifacts in fMRI signal is to include head position parameters as
nuisance covariates in regression analyses. This Matlab script (ZIP archive) uses the Pythagorean Theorem
to calculate the magnitude of head movement in the scanner, while conserving degrees of freedom by
condensing 3D head position estimates into 1D displacement and motion vectors.
Eckert, M.A., Kuchinsky, S.E., Vaden, K.I., Cute, S.L., Spampinato, M.V., Dubno, J.R. (2013).
White matter hyperintensities predict low frequency hearing in older adults.
Journal of the Association for Research in Otolaryngology. [PMID: 23512682]
Vaden, K.I., Gebregziabher, M., Kuchinsky, S.E., Eckert, M.A. (2012).
Multiple imputation of missing fMRI data in whole brain analysis.
NeuroImage, 60(3), 1843-1855. [PMID: 22500925]
Kuchinsky, S.E., Ahlstrom, J.B., Vaden, K.I., Cute, S.L., Humes, L.E., Dubno, J.R., Eckert, M.A.
(2012). Pupil size varies with word listening and response selection difficulty in older adults
with hearing loss. Psychophysiology, 50(1), 23-34. [PMID: 23157603]
Eckert, MA, Cute, SL, Vaden, KI, Kuchinsky, SE, Dubno, JR. (2012). Auditory cortex signs of age-related
hearing loss.Journal of the Association for Research in Otolaryngology, 13(5), 703-713.
Kuchinsky, S.E., Vaden, K.I., Keren, N.I., Harris, K.C., Ahlstrom, J.B., Dubno, J.R., Eckert, M.A. (2012).
Word intelligibility and age predict visual cortex activity during word listening.
Cerebral Cortex, 22(6), 1360-1371. [PMID: 21862447]
Isenberg, A, Vaden, KI, Saberi, K, Muftuler, LT, Hickok, GS. (2012). Functionally distinct regions for
spatial processing and sensory motor integration in the planum temporale. Human Brain Mapping, 33(10),
2453-2463. [PMID: 21932266]
Vaden, K.I., Kuchinsky, S.E., Keren, N.I., Harris, K.C., Ahlstrom, J.B., Dubno, J.R., Eckert, M.A.
(2011). Inferior frontal sensitivity to common speech sounds is amplified by increasing word
intelligibility. Neuropsychologia, 49(13), 3563-3572. [PMID: 21925521]
Vaden, K.I., Piquado, T., Hickok, G. (2011). Sublexical properties of spoken words modulate activity in Broca’s area but not
superior temporal cortex: implications for models of speech recognition. Journal of Cognitive Neuroscience, 23(10), 2665-2674.
Vaden, K. I., Muftuler, L.T., Hickok, G. (2010). Phonological repetition-suppression in bilateral superior temporal sulci.
Neuroimage, 49, 1018-1023.
Vaden, K.I. (2009). Phonological processes in speech perception. (Doctoral thesis, University of California, Irvine).
NOTE: Webpage refreshes after 1-2 seconds, then the download link appears.
Vaden, K.I., Kuchinsky, S.E., Cute, S.L., Ahlstrom, J.B.,
Dubno, J.R., Eckert, M.A. (2012). Anterior insula and frontal operculum
support word recognition in younger and older adults. Society for
Neuroscience, New Orleans, LA.
Vaden, K.I., Gebregziabher, M., Kuchinsky, S.E., Eckert,
M.A. (2012). Multiple imputation toolkit for group level fMRI statistics.
13th Annual Frontiers in Neuroscience Research Day: Neurodegenerative
Disorders, Seabrook, SC.
Vaden, K.I., Kuchinsky, S.E., Cute, S.L., Ahlstrom, J.B.,
Dubno, J.R., Eckert, M.A. (2011). An fMRI study of age-related changes
in sustained attention and word recognition. 4th Biennial Aging and
Speech Communication Conference, Bloomington, IN.
Vaden, K., Keren, N.I., Harris, K.C., Ahlstrom, J.B.,
Dubno, J.R., Eckert, M.A. (2010). Sublexical processing in left inferior
frontal gyrus depends on word intelligibility. Neurobiology of Language
Conference; Society for Neuroscience, San Diego, CA.
Vaden, K. & Hickok, G. (2009). Sublexical and lexical
processing in temporal and frontal lobes during word recognition.
Society for Neuroscience, Chicago, IL.
Vaden, K. & Hickok, G. (2009). Adaptation to
phonologically similar words in bilateral Superior Temporal Sulci.
Cognitive Neuroscience Society, San Francisco, CA.
Updated: April 09, 2013.